CJC-1295 / Ipamorelin Blend
CJC no DAC + Ipamorelin · CJC/Ipa
The canonical growth-hormone stack — a GHRH analogue and a selective secretagogue in one vial.
Class
CJC-1295 (no DAC) + Ipamorelin blend
Half-life
~30 min (CJC) + ~2 h (ipamorelin)
Evidence
Animal models
Animal models
Evidence comes primarily from rodent or other animal studies. Translation to humans is unproven.
Overview
This is the most popular growth-hormone pairing in one vial. CJC-1295 (no DAC) increases the amplitude of each natural GH pulse, while ipamorelin — a highly selective ghrelin-mimetic — increases pulse frequency through a separate receptor. Together they produce a larger, cleaner GH release than either alone, which is exactly why they are so often combined.
The blend inherits the secretagogue class's honest limitation: effects on body composition and recovery are inferred from GH physiology and anecdote rather than proven in controlled human trials. Ipamorelin's selectivity keeps cortisol and prolactin effects minimal, making this one of the better-tolerated GH stacks.
How it works
- CJC-1295 (no DAC) agonises pituitary GHRH receptors, raising GH pulse amplitude.
- Ipamorelin agonises the GHS-R ghrelin receptor, raising pulse frequency with high selectivity.
- The two pathways synergise for a larger, physiological GH pulse.
What the research shows
Researched effects
- Amplified GH and downstream IGF-1 (pharmacology data)
- Anecdotal recovery, sleep, and body-composition benefits
- Minimal cortisol/prolactin elevation due to ipamorelin's selectivity
Limitations & what it won't do
- No controlled human body-composition trials.
- Must be dosed away from food to preserve the GH pulse.
- Modest, gradual effects — not comparable to exogenous GH.
Dosing protocols
These ranges reflect published trials and community protocols. They are reference information, not a prescription. Doses are per injection unless noted.
Standard GH stack protocol
100 mcg CJC + 100–200 mcg ipamorelin (per component)A 5/5 or 10/10 mg blend delivers the two in a fixed 1:1 ratio, which matches the usual protocol.
Reconstitution & measuring your dose
Handling
- Typical vial sizes
- 10 · 20 mg
- Suggested BAC water
- 2 mL
- Storage
- Lyophilised powder refrigerated at 2–8 °C, protected from light.
- After reconstitution
- Reconstituted: approximately 30 days refrigerated.
Why 2 mL? A 5/5 mg blend vial (10 mg total) in 2 mL yields 5 mg/mL total, or 2500 mcg/mL of each peptide — so a combined 100/100 mcg dose lands on 4 units of a U-100 syringe.
Dose calculator
Draw to
2units
= 0.02 mL · 100 mcg per unit
Concentration
10000 mcg/mL
Doses per vial
100
Side effects
Common
- Facial flushing / head rush after injection
- Water retention
- Increased hunger
- Vivid dreams (pre-bed)
- Injection-site irritation
Serious / rare
- Reduced insulin sensitivity with prolonged use
- Theoretical tumour stimulation via IGF-1
Contraindications & interactions
Do not use if you have
- Active cancer or current oncology treatment
Raises IGF-1; contraindicated during active malignancy.
- Pregnant, breastfeeding, or trying to conceive
No pregnancy safety data.
Use caution if you have
- Type 2 diabetes or insulin resistance
GH pulses reduce insulin sensitivity — monitor glucose.
- Past cancer diagnosis (in remission)
IGF-1 elevation warrants oncology clearance.
- Carpal tunnel or nerve compression
Fluid retention can aggravate nerve compression.
Medication interactions
- monitorInsulin — GH opposes insulin; glucose may run higher.
- cautionGrowth hormone (rhGH) — Redundant with exogenous rhGH.
- monitorCorticosteroids — Steroids blunt the GH response.
What to monitor
- Fasting glucose and HbA1c
- IGF-1 if available
- Fluid status
Commonly combined with
References
- See component profilesCJC-1295 (no DAC) and Ipamorelin
Research & educational information only — not medical advice.
You must be 18 or older to use this site. The peptides described are presented as research chemicals intended for research purposes only. Most are not approved by the FDA for human use. Dosing ranges reflect what has appeared in the scientific literature or community protocols and are not prescriptions. Nothing here replaces evaluation by a licensed physician who knows your full medical history.
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