Selank
TP-7 · Tuftsin analogue
An anxiolytic neuropeptide developed in Russia — calming without the sedation of benzodiazepines.
Class
Synthetic tuftsin analogue / anxiolytic peptide
Half-life
Short; effects outlast plasma levels
Evidence
Limited human data
Limited human data
Small open-label studies, case series, or trials in a narrow population. Directionally informative, not conclusive.
Overview
Selank is a synthetic analogue of tuftsin, an immunomodulatory peptide, engineered for stability. Like Semax it originated in Russian pharmacology and is used there clinically — in Selank's case primarily as an anxiolytic for generalised anxiety.
Its appeal is the reported anxiety reduction without the sedation, dependence, or cognitive dulling associated with benzodiazepines. Proposed mechanisms include modulation of GABA and serotonin systems and stabilisation of enkephalins (endogenous opioids), plus effects on BDNF.
As with Semax, the clinical evidence is largely Russian and not replicated to Western standards. Small trials report anxiolytic effect comparable to benzodiazepines with a cleaner side-effect profile, but it is not FDA approved and rigorous Western data is scarce.
How it works
- Modulates GABAergic and serotonergic neurotransmission.
- Inhibits enkephalin-degrading enzymes, stabilising endogenous opioid signalling.
- Increases BDNF expression.
- Immunomodulatory effects inherited from its tuftsin origin.
What the research shows
Researched effects
- Reported anxiolytic effect comparable to benzodiazepines in Russian trials, without sedation
- Reported improvement in generalised anxiety symptoms
- Anecdotal reduction in anxiety and improved focus
- Possible immunomodulatory and antiviral signals
Limitations & what it won't do
- Western controlled trials are largely absent.
- Not FDA approved.
- Intranasal dosing and bioavailability not well standardised.
Dosing protocols
These ranges reflect published trials and community protocols. They are reference information, not a prescription. Doses are per injection unless noted.
Intranasal anxiolytic protocol (community)
250–500 mcg (0.15% or higher solution)Confirm solution concentration before dosing. Often paired with Semax.
Administration
Not an injectable reconstitution compound
Side effects
Common
- Nasal irritation
- Mild drowsiness in some users
- Occasional headache
Serious / rare
- Poorly characterised in Western literature
Contraindications & interactions
Do not use if you have
- Pregnant, breastfeeding, or trying to conceive
No pregnancy safety data.
Use caution if you have
- Mood or psychiatric condition
Discuss with a prescriber before layering onto treatment for a mood or anxiety disorder.
Medication interactions
- cautionSSRIs / SNRIs — Serotonergic modulation on top of an SSRI/SNRI is unstudied.
- cautionOpioid analgesics — Enkephalinase inhibition may interact with opioid therapy.
What to monitor
- Anxiety and mood
- Sleep quality
Commonly combined with
References
Research & educational information only — not medical advice.
You must be 18 or older to use this site. The peptides described are presented as research chemicals intended for research purposes only. Most are not approved by the FDA for human use. Dosing ranges reflect what has appeared in the scientific literature or community protocols and are not prescriptions. Nothing here replaces evaluation by a licensed physician who knows your full medical history.
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