Semax / Selank Blend
Semax + Selank
A nootropic-plus-anxiolytic pairing — focus from Semax, calm from Selank, in one nasal formula.
Class
Semax + Selank neuropeptide blend
Half-life
Short (both)
Evidence
Limited human data
Limited human data
Small open-label studies, case series, or trials in a narrow population. Directionally informative, not conclusive.
Overview
This blend pairs the two best-known Russian neuropeptides: Semax, used for focus, cognition, and neuroprotection, and Selank, an anxiolytic that calms without sedation. The idea is a balanced 'focused-but-calm' state — the stimulation and BDNF support of Semax offset by Selank's anti-anxiety effect.
Both components have Russian clinical use and limited Western validation, so the blend inherits that mixed evidence picture. It is typically delivered intranasally. Anyone managing a mood or anxiety disorder should involve a prescriber, since both peptides touch serotonergic and other neurotransmitter systems.
How it works
- Semax raises BDNF/NGF and modulates dopamine and serotonin for focus and neuroprotection.
- Selank modulates GABA and serotonin systems and stabilises enkephalins for anxiolysis.
- Combined, they aim for alert focus without the overstimulation Semax can cause alone.
What the research shows
Researched effects
- Focus, mental stamina, and neuroprotection (Semax, Russian data)
- Anxiety reduction without sedation (Selank, Russian data)
- Anecdotal 'calm focus' from the combination
Limitations & what it won't do
- Western controlled trials are largely absent for both.
- Intranasal dosing and concentration vary; confirm before dosing.
- Not FDA approved.
Dosing protocols
These ranges reflect published trials and community protocols. They are reference information, not a prescription. Doses are per injection unless noted.
Intranasal protocol (community)
250–500 mcg of each (per component)Confirm the blend's per-peptide concentration before dosing.
Reconstitution & measuring your dose
Handling
- Typical vial sizes
- 20 mg
- Suggested BAC water
- 2 mL
- Storage
- Refrigerate, protected from light.
- After reconstitution
- Reconstituted: approximately 20–30 days refrigerated.
Why 2 mL? A 10/10 mg blend (20 mg total) is typically formulated into a metered nasal spray rather than injected.
Dose calculator
Draw to
2.5units
= 0.025 mL · 100 mcg per unit
Concentration
10000 mcg/mL
Doses per vial
80
Side effects
Common
- Nasal irritation
- Mild headache
- Possible drowsiness (Selank) or overstimulation (Semax)
Serious / rare
- Poorly characterised in Western literature
Contraindications & interactions
Do not use if you have
- Pregnant, breastfeeding, or trying to conceive
No pregnancy safety data.
Use caution if you have
- Mood or psychiatric condition
Both modulate neurotransmitters; involve a prescriber for mood/anxiety disorders.
- Seizure disorder
CNS-active — caution with a seizure history.
Medication interactions
- cautionSSRIs / SNRIs — Serotonergic modulation on top of an SSRI/SNRI is unstudied.
- cautionMAO inhibitors — Combining neuromodulators with MAOIs is poorly characterised.
What to monitor
- Mood, anxiety, and sleep
- Subjective cognitive effect
Commonly combined with
References
- See component profilesSemax and Selank
Research & educational information only — not medical advice.
You must be 18 or older to use this site. The peptides described are presented as research chemicals intended for research purposes only. Most are not approved by the FDA for human use. Dosing ranges reflect what has appeared in the scientific literature or community protocols and are not prescriptions. Nothing here replaces evaluation by a licensed physician who knows your full medical history.
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