DSIP
Delta Sleep-Inducing Peptide
A naturally occurring nonapeptide studied for sleep, stress resilience, and pain modulation.
Class
Delta sleep-inducing neuropeptide
Half-life
Very short (minutes)
Evidence
Limited human data
Limited human data
Small open-label studies, case series, or trials in a narrow population. Directionally informative, not conclusive.
Overview
DSIP is a nine-amino-acid peptide first isolated from the brains of sleeping rabbits, named for its ability to promote delta-wave (deep) sleep. In humans it has been studied for insomnia, stress, chronic pain, and even alcohol/opioid withdrawal, though the body of evidence is old and modest.
Its behaviour is unusual: rather than sedating like a hypnotic, it appears to normalise sleep architecture and stress hormones, which is why some studies found benefit for disrupted rather than simply insufficient sleep. It crosses the blood-brain barrier despite its size.
How it works
- Modulates sleep architecture toward deeper, delta-wave-dominant stages rather than sedating.
- Influences the hypothalamic-pituitary-adrenal axis, blunting stress-hormone responses.
- Interacts with opioid and other neurotransmitter systems, relevant to its studied pain and withdrawal effects.
What the research shows
Researched effects
- Improved sleep onset and quality in some small human studies of chronic insomnia
- Reduced stress-hormone (cortisol) responses
- Reported analgesic and anti-withdrawal effects in older clinical reports
Limitations & what it won't do
- Human evidence is limited, dated, and inconsistent.
- Very short half-life; timing relative to sleep matters.
- Not FDA approved.
Dosing protocols
These ranges reflect published trials and community protocols. They are reference information, not a prescription. Doses are per injection unless noted.
Sleep protocol (community)
100–300 mcgDocumented for reference; human efficacy is modest and inconsistent.
Reconstitution & measuring your dose
Handling
- Typical vial sizes
- 10 mg
- Suggested BAC water
- 2 mL
- Storage
- Lyophilised powder refrigerated at 2–8 °C, protected from light.
- After reconstitution
- Reconstituted: approximately 30 days refrigerated.
Why 2 mL? A 10 mg vial in 2 mL yields 5000 mcg/mL — 100 mcg lands on 2 units of a U-100 syringe. For easier measurement of small doses, reconstitute in more water.
Dose calculator
Draw to
2units
= 0.02 mL · 50 mcg per unit
Concentration
5000 mcg/mL
Doses per vial
100
Side effects
Common
- Grogginess if dosed too late
- Injection-site irritation
- Generally well tolerated
Serious / rare
- Poorly characterised in modern trials
Contraindications & interactions
Do not use if you have
- Pregnant, breastfeeding, or trying to conceive
No pregnancy safety data.
Use caution if you have
- Mood or psychiatric condition
Sleep and mood are tightly linked; discuss with a prescriber if treating a mood disorder.
Medication interactions
- cautionOpioid analgesics — DSIP interacts with opioid systems; combining with opioid therapy is not well characterised.
- monitorSSRIs / SNRIs — Serotonergic sleep effects may overlap.
What to monitor
- Sleep quality and daytime alertness
Commonly combined with
References
Research & educational information only — not medical advice.
You must be 18 or older to use this site. The peptides described are presented as research chemicals intended for research purposes only. Most are not approved by the FDA for human use. Dosing ranges reflect what has appeared in the scientific literature or community protocols and are not prescriptions. Nothing here replaces evaluation by a licensed physician who knows your full medical history.
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